The application of nitrogen-filled sealing machines in the pharmaceutical industry

In the pharmaceutical industry, nitrogen-filled sealing machines play a crucial role in multiple aspects such as drug protection, packaging, storage, and maintenance of medical equipment by creating an oxygen-free environment. Their specific applications are as follows:

1. Drug protection: prevent oxidation and degradation
Solid drugs (tablets, capsules)
Nitrogen can isolate oxygen, prevent the active ingredients in the drug (such as vitamin C, adrenaline) from being oxidized and decomposed, and ensure the stability of the drug effect. For example, after a certain brand of vitamin C tablets were packed with nitrogen, the retention rate of the active ingredients increased by 20%.

Liquid drugs (injection, oral solution)
Filling nitrogen during the preparation and filling process of the drug solution can reduce oxygen contact and prevent oxidation and deterioration. For example, after the antibiotic injection solution was packed with nitrogen, the shelf life was extended from 12 months to 24 months.

Powders and ointments
Nitrogen filling can delay drug degradation and extend the shelf life. After a Chinese medicine ointment was packed with nitrogen, the microbial growth rate was reduced by 50%.

2. Drug packaging: ensure sterility and safety
Packaging of sterile preparations
The nitrogen filling sealer removes oxygen during the packaging process to form a sterile environment and reduce the risk of bacterial contamination. For example, after a vaccine manufacturer adopted nitrogen packaging, the product qualification rate increased from 95% to 99.5%.

Blister-packaged medicines
Nitrogen replaces the air in the package to prevent the medicine from absorbing moisture, agglomerating, or oxidizing and deteriorating. After the blister packaging of a certain brand of cold medicine was filled with nitrogen, the tablet breakage rate dropped from 3% to 0.5%.

Special dosage form protection

Flammable and explosive raw materials: Dangerous raw materials such as alcohol can be stored in a closed nitrogen environment to prevent volatilization and explosion.
Biologics: Nitrogen environment can maintain the activity of biological agents and extend the shelf life.
III. Drug storage and transportation: Extending the shelf life
Freezing drugs
Nitrogen filling can prevent ice crystals from forming during low-temperature storage and maintain stability. For example, after a biopharmaceutical company adopted nitrogen-filled cryopreservation technology, the drug activity loss rate dropped from 15% to 5%.

Transport protection
Nitrogen-filled packaging can buffer the impact during transportation and prevent drug damage. At the same time, the positive pressure environment of nitrogen can prevent external moisture from penetrating and keep the drugs dry.

IV. Medical equipment maintenance: Ensure normal operation
Equipment power source
Nitrogen can be used as a power source or working medium for medical equipment such as anesthesia machines and infusion pumps to ensure stable operation of the equipment.

Equipment protection
Filling medical equipment with nitrogen during storage and transportation can prevent oxidation and corrosion of internal components of the equipment and extend its service life.

V. Laboratory and scientific research: ensuring sample integrity
Biological sample preservation
Cells, tissues, blood and other biological samples are sensitive to oxygen. Nitrogen filling and sealing machines can provide a stable, oxygen-free storage environment to extend survival time. For example, after a laboratory adopted nitrogen filling packaging, the cell survival rate increased from 70% to 95%.

Experimental material protection
Chemical reagents, culture dishes and other experimental materials need to be stored for a long time and are sensitive to oxygen. Nitrogen filling and sealing machines can ensure their integrity and stability.

VI. Technical advantages support medical applications
High-purity nitrogen supply
Modern nitrogen filling and sealing machines use pressure swing adsorption molecular sieve technology to provide nitrogen with a purity of ≥99.9%, meeting the strict requirements of the pharmaceutical industry for gas purity.

Intelligent control system
PLC programmable controller combined with touch screen supports precise setting of parameters such as vacuum degree, sealing temperature, and nitrogen filling time to ensure the packaging process is sterile and oxygen-free.

Residual oxygen control
The residual oxygen content in the package is controlled to ≤3% through high-precision pressure sensors and flow meters, meeting the high standards of the pharmaceutical industry.